Tough call.
As an intoxicant, weed. I had a few blasts on my mate's new electric smokeless bong a few weekends ago. It took a while to hit but when it did, it was brilliant. We'd pick up one line from whatever we were watching - Return Of The Jedi at one point - and make a connection to something else, then make jokes for a full ten minutes about it and crack each other completely up, running the joke into the ground, before waiting for something else to hit us. I've never laughed so hard. Completely stoned bonkers, no smoke, no lingering smell. Thankfully it wore off so we were normal when we went out with friends to drink 5AM Saint and Punk IPA in Brewdog....
... ultimately I voted booze, because I actually love the taste of a vast variety of ales, bitters, malt whiskeys, rum, shooters, cocktails, fruit ciders and so on. Even if I don't go out "to get pissed" I can't imagine chatting and playing darts over a coke rather than a smooth pint of my local bitter. Mm-mm.
But hey, if everything was legal and there were no long-lasting medical effects.... marching powder. Calm down, I don't do it any more, it was a long time ago and I wouldn't recommend it to anyone impressionable. But when I was doing it, it was amazing, and I loved it.