For quantity, gotta go with damn near ALL the Villains of Old Detriot City in Robocop. Clarence Boddicker, The Corporate Jerk-offs - Bob Morton, OCP Vice President Richard “Dick” Jones, and last but not least, the robot that will shoot your ass for a parking violation, ED-209.
Albert Wesker was alright in Code Veronica (but a joke in the 5th one) but I'd say the overall best villain in Resident Evil was Krauser in RE4. The battle with him on top of the ruins was awesome
Did anyone note Pacino in Scarface yet? Man that's one of the greatest villians ever. He should've got the Oscar for that performance. Hard as shit to find footage on the Tube though.